![]() Donepezil (Aricept®): approved to treat all stages of Alzheimer’s disease.The cholinesterase inhibitors most commonly prescribed are: These drugs support communication between nerve cells. These medications prevent the breakdown of acetylcholine (a-SEA-til-KOHlean), a chemical messenger important for memory and learning. Cholinesterase inhibitors (Aricept®, Exelon®, Razadyne®)Ĭholinesterase (KOH-luh-NES-ter-ays) inhibitors are prescribed to treat symptoms related to memory, thinking, language, judgment and other thought processes. The following medications are prescribed to treat symptoms related to memory and thinking. While these medications do not stop the damage Alzheimer’s causes to brain cells, they may help lessen or stabilize symptoms for a limited time by affecting certain chemicals involved in carrying messages among and between the brain's nerve cells. It usually resolves over time.ĭrugs that treat symptoms Cognitive symptoms (memory and thinking)Īs Alzheimer’s progresses, brain cells die and connections among cells are lost, causing cognitive symptoms to worsen. It is typically a temporary swelling in areas of the brain. The most common reported serious side effects were infusion-related reactions and amyloid-related imaging abnormalities (ARIA), a common side effect that does not usually cause symptoms but can be serious. These people should also have confirmation of elevated beta-amyloid plaques in the brain. This drug is approved for people with early Alzheimer's disease (mild cognitive impairment (MCI) or mild dementia due to Alzheimer's disease). Lecanemab (Leqembi™) is an anti-amyloid antibody intravenous (IV) infusion therapy approved for early Alzheimer's with confirmation of elevated beta-amyloid. Some may have symptoms of ARIA such as headache, dizziness, nausea, confusion and vision changes. Some people may also have small spots of bleeding in or on the surface of the brain with the swelling, although most people with swelling in areas of the brain do not have symptoms. It is typically a temporary swelling in areas of the brain that usually resolves over time. ARIA is a common side effect that does not usually cause symptoms but can be serious. Another potentially serious side effect is allergic reaction. The most common side effects include amyloid-related imaging abnormalities (ARIA), headache and fall. Performing household chores such as cleaning.Examples of functional measures include:.Examples of cognition measures include:.Some clinical trial participants who received aducanumab experienced reduction in cognitive decline observed through measures of cognition and function.There is no safety or effectiveness data on initiating treatment at earlier or later stages of the disease than were studied.Treatment with aducanumab may be appropriate for people in the disease stage studied in the clinical trials. The drug was studied in people living with early Alzheimer’s disease - which includes people with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's disease who also have evidence of a buildup of amyloid plaques in the brain.Aducanumab is indicated for the treatment of Alzheimer’s disease.Each works differently and targets beta-amyloid at a different stage of plaque formation.Īducanumab is an anti-amyloid antibody intravenous (IV) infusion therapy approved for early Alzheimer's disease, including people living with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's disease.Īducanumab was the first therapy to demonstrate that removing beta-amyloid from the brain reduces cognitive and functional decline in people living with early Alzheimer’s. They aim to slow the decline of memory and thinking, as well as function, in people living with Alzheimer's disease.Īnti-amyloid treatments work by attaching to and removing beta-amyloid, a protein that accumulates into plaques, from the brain. Drugs that change disease progressionĭrugs in this category slow disease progression by going after the underlying biology of the disease process. A clinician who is experienced in using these types of medications should monitor people who are taking them and ensure that the recommended guidelines are strictly observed. When considering any treatment, it is important to have a conversation with a health care professional to determine whether it is appropriate. The FDA has approved medications that fall into two categories: drugs that change disease progression in people living with early Alzheimer's disease, and drugs that may temporarily mitigate some symptoms of Alzheimer's dementia. ![]()
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